Thyroid hormone has many effects on the heart and vascular system.1Many of the clinical manifestations of hyperthyroidism are dueto the ability of thyroid hormone to alter cardiovascular hemodynamics.2The hemodynamic effects of hypothyroidism are opposite to thoseof hyperthyroidism, although the clinical manifestations areless obvious. This review will integrate what is known aboutthe mechanisms of thyroid hormone action on the heart2,3,4,5with recent observations from both experimental and clinicalstudies of hyperthyroidism and hypothyroidism. We will alsoaddress the potential role of thyroid hormone treatment in patientswith acute or chronic cardiac disease.
Effects of Thyroid Hormone on Myocardial Contractility and Hemodynamics
Changes in Thyroid Function That Accompany Heart Disease
Conclusions
Source Information
From the Division of Endocrinology, Department of Medicine, North Shore University Hospital, Manhasset, N.Y., and the Departments of Medicine and Cell Biology, New York University School of Medicine, New York.
Address reprint requests to Dr. Klein at the Division of Endocrinology, North Shore University Hospital, 300 Community Dr., Manhasset, NY 11030, or at iklein@nshs.edu.
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