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Correction to Bosch et al., N Engl J Med 361(1):62-72 July 2, 2009.

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Volume 361:1411-1413 October 1, 2009 Number 14
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Rhabdomyolysis and Acute Kidney Injury

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by Bosch, X.
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To the Editor: Bosch and colleagues (July 2 issue)1 observe that although conventional hemodialysis filters do not remove myoglobin (molecular weight, 17.8 kD), hemodiafiltration with super-high-flux dialyzers may be effective.2 We used a hemodialysis prescription with a super-high-flux dialyzer (HCO-1100, Gambro) that efficiently removed molecules of up to 60 kD. In two patients with rhabdomyolysis and acute kidney injury, the mean serum myoglobin clearance with a single dialysis treatment was 59%.3 A 4-hour dialysis treatment cleared myoglobin from the equivalent of 9 liters of extravascular fluid (twice the intravascular volume). The kinetics of myoglobin that we observed were similar to . . . [Full Text of this Article]



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