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Clinical Implications of Basic Research
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Volume 361:526-528 July 30, 2009 Number 5
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Platelets, Pyrexia, and Plasmodia
Doron C. Greenbaum, Ph.D., and Garret A. FitzGerald, M.D.

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Platelets have long been known to interact cooperatively with erythrocytes in thrombogenesis, both generally and in patients with sickle cell disease.1 Recently, the molecular mechanisms by which neutrophils can bridge their interactions with endothelial cells have begun to be elucidated.2 A recent study by McMorran et al.3 raises the possibility that platelet–erythrocyte interactions might be clinically felicitous in patients with malaria. This disease is caused, in humans, by four parasites of the plasmodium genus: Plasmodium falciparum, P. vivax, P. ovale, and P. malariae. P. falciparum malaria is associated with the majority of deaths from malaria worldwide, . . . [Full Text of this Article]


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From the Department of Pharmacology and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia.



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