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Clinical Implications of Basic Research
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Volume 358:304-305 January 17, 2008 Number 3
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Guiding Aerosol Deposition in the Lung
Allan L. Coates, M.D., C.M.

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-PubMed Citation
Direct delivery of aerosolized medication to the diseased lung allows therapy to be targeted, albeit with challenges. A study recently reported by Dames et al.1 underscores the magnet as an attractive means of fine-tuning drug delivery.

The lung has a large surface area, and the cross-sectional area of the airways increases distally, which slows the velocity of flow. The deposition of an inhaled aerosol occurs through three mechanisms (Figure 1).2 The first is inertial impaction, in which a droplet fails to turn a corner and impacts the wall of the airway. The second is sedimentation, in which the . . . [Full Text of this Article]


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From the Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto.




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