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Previous Volume 361:62-72 July 2, 2009 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Rhabdomyolysis — literally, the dissolution of striped (skeletal) muscle — is characterized by the leakage of muscle-cell contents, including electrolytes, myoglobin, and other sarcoplasmic proteins (e.g., creatine kinase, aldolase, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) into the circulation. Massive necrosis, which is manifested as limb weakness, myalgia, swelling, and, commonly, gross pigmenturia without hematuria, is the common denominator of both traumatic and nontraumatic rhabdomyolysis.^1,2 Acute kidney injury is a potential complication of severe rhabdomyolysis, regardless of whether the rhabdomyolysis is the result of trauma or some other cause, and the prognosis is substantially worse if renal failure develops. In . . . [Full Text of this Article]

Epidemiology of Myoglobinuria-Induced Acute Kidney Injury

Pathogenesis of Myoglobin-Induced Acute Kidney Injury

Renal Manifestations of Rhabdomyolysis

Treatment and Prevention

Source Information

From the Muscle Research Unit, Department of Internal Medicine (X.B., J.M.G.), and the Department of Nephrology (E.P.), Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona.

Address reprint requests to Dr. Grau at the Muscle Research Unit, Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 170 08036-Barcelona, Spain, or at jmgrau@clinic.ub.es, or to Dr. Poch at the Department of Nephrology, Hospital Clínic, Villaroel 170, 08036-Barcelona, Spain, or at epoch@clinic.ub.es.

Related Letters:

Rhabdomyolysis and Acute Kidney Injury
Basnayake K., Cockwell P., Hutchison C. A., Heyne N., Guthoff M., Weisel K. C., Poch E., Bosch X., Grau J. M.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:1411-1413, Oct 1, 2009. Correspondence

This article has been cited by other articles:

• Ayala, E., Kagawa, F. T., Wehner, J. H., Tam, J., Upadhyay, D. (2009). Rhabdomyolysis Associated With 2009 Influenza A(H1N1). JAMA 302: 1863-1864 [Full Text]  
• Basnayake, K., Cockwell, P., Hutchison, C. A., Heyne, N., Guthoff, M., Weisel, K. C., Poch, E., Bosch, X., Grau, J. M. (2009). Rhabdomyolysis and Acute Kidney Injury. NEJM 361: 1411-1413 [Full Text]