The capacity of the heart to regenerate functional myocardiumis extremely limited or absent. This lack of regenerative capacitycontrasts with that of many other organs and tissues. Heartfailure remains the leading cause of hospitalization in theUnited States, and its prevalence continues to grow as the populationages. In most patients, the underlying cause of heart failureis a loss of cardiomyocytes, accompanied by functional derangementsin contraction and relaxation. The traditional view has heldthat the reparative ability of the heart is limited by the inabilityof terminally differentiated cardiomyocytes to undergo celldivision after the first . . . [Full Text of this Article]
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From the Cardiovascular Institute, the Department of Medicine (M.S.P., J.A.E.), and the Department of Cell and Developmental Biology (J.A.E), University of Pennsylvania, Philadelphia.
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